Correspondence to 2007; https://doi.org/10.1186/1475-2867-7-4. 1987;161(2):559–66. Zingiber Zerumbet Smith is a tall upright ginger growing up to 3m tall with long, narrow leaves. Blood was collected by cardiac puncture in plain tubes and centrifuged at 3000 rpm for 10 min to obtain serum. Zingiber zerumbet (L.) Smith, locally known in Malaysia as “lempoyang” is one of the commonly used wild ginger species in Malays traditional medicine. PubMed  Rains JL, Jain SK. AH, FWI and MAL reviewed the manuscript. Neuron cells in in the cerebral cortex undergo necrosis with pyknotic characteristic such as darken nucleus and lost its morphology. Some probably aren't as safe as you'd hope. Plant Name. Cohen-Kerem R, Koren G. Antioxidants and fetal protection against ethanol teratogenicity I. The rats were then sacrificed. Antioxidants are used to scavenge ROS [9]. Binge ethanol exposure in adult rats causes necrotic cell death. Associate Professor Asmah Hamid, Farah Wahida Ibrahim, Dr. Mazlyzam Abdul Latif, Teoh Hooi Ming, Mohd Nazir Nasrom, Norelina Eusoff: member of Biomedical Science Programme, Centre of Health & Applied Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia and associate professor Khairana Husain: Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. 2004;572(1–3):245–50. Malondialdehyde (MDA) level is an index to determine lipid peroxidation process (Ledwozyw et al. It is used in local traditional medicine as a … Maralla S, Reddy KS. Thus, it could be speculated that Z. zerumbet extract may induce GSH synthesis by protecting the brain against ethanol-induced damage through similar mechanism. Zingiber spurium J.König. Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments. Baker KG, Harding AJ, Halliday GM, Kril JJ, Harper CG. PubMed  [18] and Abdul Hamid et al. The relationship between plasma triglycerides, cholesterol, total lipids and lipid peroxidation products during human atherosclerosis. 1986) [23]. In contrast, treatment with Z. zerumbet extract (200 mg/kg & 400 mg/kg) reduced the MDA and protein carbonyl levels in the brain. Treatment with Z. zerumbet extract at 200 mg/kg and 400 mg/kg significantly increased (p < 0.05) the SOD, CAT and GPx enzyme activities in serum samples. 2001;298(2):737–43. Zerumbone induced apoptosis in liver cancer cells via modulation of Bax/Bcl-2 ratio. Human anterior cingulate cortex neurons encode cognitive and emotional demands. Zingiber officinale extract was a potential brain tonic to enhance cognitive function for ethanol-related cognitive deficits [ 16 ]. Zingiber cochinchinense Gagnep. GPx enzyme activity was assayed according to the procedure described by Paglia & Valentine [27] based on the oxidation rate of glutathione (GSH) by H2O2 in the presence of GPx. Aoyama K, Watabe M, Nakaki T. Regulation of neuronal glutathione synthesis. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Zingiber zerumbet rhizomes were supplied from herbs farm (Kizaherbs Sdn Bhd) in Temerloh, Pahang, Malaysia. In normal condition, ROS and antioxidants are in a balanced state. 1b). This indicates that the amount of antioxidant compounds present in Z. zerumbet contributes significantly to its antioxidant property [18]. Kruk-Slomka M, Boguszewska-Czubara A, Slomka T, Budzynska B, Biala G. Correlations between the memory-related behavior and the level of oxidative stress biomarkers in the mice brain, provoked by an acute administration of CB receptor ligands. The antioxidant protective properties of polyphenol and flavonoid components of the extract possibly increase the antioxidative defence mechanism of the cells. Increased SOD, CAT and GPx activities in this study may relate to the fact that the high antioxidant activities in Z.zerumbet extract induced endogenous antioxidant thus reduced the free radical activity [41]. SOD activity was assayed based on the procedure described by Beyer & Fridovich [25]. However, Z. zerumbet administration appeared to cause less oxidative stress condition as its ability to reduce protein and lipid oxidation and increase the antioxidant defense mechanism. About the Experts. Effects of chronic ethanol exposure on renal function tests and oxidative stress in kidney. Reduction of SOD activity in the brain induced by ethanol in this study may be due to the generation of excessive anion, (O2•¯) that causes this enzyme to become inactivated. New York: Wiley; 2005. p. 931. Treatment with ethyl-acetate Z. zerumbet extract at 200 mg/kg and 400 mg/kg significantly reduced the level of malondialdehyde (MDA) and protein carbonyl (p < 0.05) in the brain homogenate. She is known worldwide as The Cosmetics Cop and creator of Paula’s Choice Skincare. | Legal Disclaimer Chen BY, Lin DP, Wu CY, Teng MC, Sun CY, Tsai YT, Su KC, Wang SR, Chang HH. Alcohol Alcohol. This family of ginger was found to reduce the brain infarct volume and decrease oxidative stress in the cerebral cortex and hippocampus. In the current study, ethanol administration decreased GPx activity and GSH level both in serum and brain homogenate. Rats in Group 1 received normal saline (normal), Group II were ethanol-induced group where ethanol was administrated intraperitoneally at the dose of 1.8 g/kg− 1(40% v/v). (EtOH: ethanol; 200 + EtOH: 200 mg/kg extract + ethanol; 400 + EtOH: 400 mg/kg extract + ethanol). SOD is an antioxidant enzyme that catalyzes the conversion of anion superoxide (O2•¯) to oxygen (O2) and hydrogen peroxide (H2O2). For the brain samples, only 400 mg/kg Z. zerumbet extract showed significant increased (p < 0.05) in the activities of these three enzymes as compared to the ethanol-induced group. 2g). Blood and brain homogenate were subjected to biochemical tests and part of the brain tissue was sectioned for histological analysis. Each crude extract of hexane, ethyl-acetate and methanol was filtered and evaporated using rotary evaporator. 2008;108(3):227–38. Remarkable protective effects were observed at 400 mg/kg as compared to a lower dose of 200 mg/kg of the extract. Afr J Biotechnol. It likes shade, and can be grown from bright shade to dark shade. Furthermore, it can disrupt the antioxidant system to cause oxidative stress [5] which eventually leads to neuronal cell death [6]. Decomposition of H2O2 by CAT enzymes was measured at 240 nm wavelength. Note the number of Purkinje cells. Marella S, Reddy KS. All figures used in the graphical abstract are free from copyright. In addition, an increase in the antioxidant activity can be described as an adaptive response to excessive ROS [42]. https://doi.org/10.5772/31366. In addition, Hamid et al. Zingiber aromaticum Valeton. https://doi.org/10.1186/s12906-018-2161-5, DOI: https://doi.org/10.1186/s12906-018-2161-5. AH, FWI and THM conceived and designed the study. Mol Asp Med. 2013;1(3):48–55. Anti-Microbial - In this study they investigated antimicrobial effects of ethanolic extract of Zingiber zerumbet (Z. zerumbet) (L.) Smith and its chloroform and petroleum ether soluble fractions against pathogenic bacteria and fungi. The flavonoid component exhibited the strongest inhibition of aldose reductase compared to … Although enzymatic activities of SOD, CAT, GPx and GSH in the Z. zerumbet treated group (200 mg/kg) were increased, but the increment were non-significant. The young stems, rhizomes … The plant was identified by a botanist and herbarium curator, Mr. Ahmad Damanhuri Mohamad from School of Environmental and Natural Resource Sciences and deposited at the Faculty of Science and Technology Herbarium, Universiti Kebangsaan Malaysia. 1a). Duration: Perennial Growth Habit: Herb/Forb Hawaii Native Status: Introduced. Review of the experimental data and implications to humans. Biomol Ther. Zingiber zerumbet (L.) Smith belongs to the Zingiberaceae family that is widely distributed throughout the tropics, particularly in Southeast Asia. Previous study was found that 2 days of highly condensed alcohol exposure during neonatal brain growth resulted in Purkinje cell loss [11]. Zerumbone is a sesquiterpene phytochemical from a type of edible ginger known as China Zingiber Zerumbet Smith grown in South China or "Zingiber aromaticum". Zerumbet zingiber T.Lestib. Supplementation with Z. zerumbet extracts at 200 mg/kg and 400 mg/kg significantly decreased (p < 0.05) MDA levels compared to the ethanol-induced group (Fig. Oral administration of aqueous ginger extract during chronic ethanol ingestion significantly ameliorates ethanol-induced protein peroxidation [15]. FEBS Lett. Google Scholar. J Pharmacol Sci. The role of oxidative stress in fetal alcohol spectrum disorders. Ledwozyw A, Michalak J, Stepień A, Kadziołka A. Alcohol can easily cross the cell membranes, including the blood-brain barrier. Developmental & Reproductive Toxicity . Z. zerumbet extract at 400 mg/kg dose gave a better protective effect against ethanol-induced brain damage and this may be due to the high amount of zerumbone present in the extract. 1959;82(1):70–7. It has cone shaped bracts. Am J Appl Sci. The resulting ROS production causes the imbalance between antioxidant and oxidative stress, that eventually will lead to neuronal cell damage [32]. Dose-Response Relationship of Zerumbone in Rat with … GSH was quantified according to the protocols as described by Ellman [28]. 1984;105:121–6. California Privacy Statement, (N = 6). Neuronal cells are highly dependent on glucose for ATP generation and the production of ROS as a product of oxidative phosphorylation in the mitochondria. 2007;104(3):1183–91. For the histological observation of the cerebellum, this study showed that the distance between any two Purkinje cells was larger in ethanol-induced rats, but a detailed and systematic calculation of the distance is required to be carried out to elucidate this issue. Used in pharmaveutical field, 3. Alcohol causes oxidative damage by producing superoxide, hydroxyl and hydroethyl radicals which may contribute to lipid peroxidation, protein carbonyl formation and DNA damage [4]. 1967;70(1):158–69. Search by keywords . Cookies policy. We aimed to investigate whether EEZZR exerts an ameliorative effect on renal damage in diabetes induced by streptozotocin (STZ). Halliwel B. Reactive species and antioxidants. [18] and Abdul Hamid et al. Methods Enzymol. That is why both cerebral cortex and cerebellum are the main target in this study. The experiment involving the animals was approved according to animal handling guidelines provided by the UKM Animal Ethics Committee (FSK/BIOMED/2012/ASMAH/21-NOV/475-NOV-2012-JUNE-2013). PubMed online scientific bibliography data. Approved on 22nd November 2012 with estimated duration of project from November 2012 to June 2013. The digestive system: absorption of alcohol. Curcumin has been reported to have high antioxidant activities that protect the brain against ethanol-induced brain damage [1, 12]. Zingiber amaricans Blume. Ruslay S, Abas F, Shaari K, Zainal Z, Sirat H, Israf DA, Lajis NH. 1998;105(2):159–66. Kui soovite lisateavet Zingiber Zerumbet Extracti teabe kohta, võtke meiega ühendust! Các nhà sản xuất Zingiber Zerumbet Extract từ Bolise.Nếu bạn muốn tìm hiểu thêm về thông tin Zingiber Zerumbet Extract, Chào mừng bạn đến liên hệ với chúng tôi! The animals were randomly divided into four groups with six rats in each group. Rout OP, Acharya R, Kumar MS. Zingiber zerumbet (L.) Smith, a reservoir plant for therapeutic uses: a review. Pharmacology. [ Latin Name ] Zingiber zerumbet (L.) Smith [ Active Ingredient ] Zerumbone [ Part Used ] Root [ Test Method ] TLC [ Appearance ] Brown fine Powder [ Application ] 1. This This study was conducted to evaluate the effects of Z. zerumbet extract in gout-induced rats. The rhizomes of Z. zerumbet are used to treat ulcerative colitis [19] to cure dyspepsia wound, hemorrhoids, and stomach discomfort [20]. Zingiber zerumbet and Curcuma xanthorrhiza are two of the most commonly used ingredients in Indo-Malaysian traditional medicines, health supplements and tonics. Alcohol is a commonly abused substance worldwide that generates reactive oxygen species (ROS) whether it is consumed acutely or chronically [1]. It was also shown that Z. officinale at the dose of 200 mg/kg body weight could protect the brain against ischemic brain damage and reduced cognitive deficits in a rat model of focal cerebral ischemia induced by the occlusion of the right middle cerebral artery. Effects of Z. zerumbet extract on serum superoxide dismutase (a), brain superoxide dismutase (b), serum catalase (c), brain catalase (d), serum glutathione peroxidase (e), brain glutathione peroxidase (f) activities and brain glutathione level (g). (EtOH: ethanol; 200 + EtOH: 200 mg/kg extract + ethanol; 400 + EtOH: 400 mg/kg extract + ethanol). See that long list of ingredients on the back of the bottle? Determination of carbonyl content in oxidatively modified protein. On the other hands, brain sections from ethanol-induced group showed that the distance between 2 Purkinje cells was large as compared to normal group. Zingiber Zerumbet Plant Extract Wuhan HHD 100% Pure Natural Plant Extract Of Zerumbone Zingiber Zerumbet Extract US $10.00-$80.00 / … Aebi H. Catalase in vitro. Where to buy Zingiber Zerumbet Extract?Zingiber Zerumbet Extract Manufacturers from Bolise.If you want to learn more about Zingiber Zerumbet Extract information, Welcome to contact us! Butterfield DA, Castegna A, Drake J, Scapagnini G, Calabrese V. Vitamin E and neurodegenerative disorders associated with oxidative stress. Zerumbone, the active compound of Z. zerumbet rhizomes protected the kidney against cisplastin-induced nephrotoxicity by blocking the MDA formation [33]. Zerumbone indirectly induced the GSH synthesis and provided intracellular protection mechanism to remove free radicals from toxic agents [33]. Prior to use, ethyl-acetate extract of Z. zerumbet was dissolved in di-methyl sulfoxide (DMSO) and diluted in phosphate buffered saline (PBS) pH 7.4. Rev Bras. This process was repeated three times. The concoction of Zingiber zerumbet rhizomes is normally drunk to treat indigestion, stomachache, fever and worm infestation. Biomedical Science Programme, Centre of Health & Applied Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia, Asmah Hamid, Farah Wahida Ibrahim, Teoh Hooi Ming, Mohd Nazir Nasrom, Norelina Eusoff & Mazlyzam Abdul Latif, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Malaysia, You can also search for this author in 2012;4(4):136–45. Learn more | Legal Disclaimer, Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Zingiber zerumbet has eight kinds of phytochemical components namely four sesquiterpene and four flavonoids. All datasets used and/or analysed during the current study available from the corresponding author on reasonable request. Z. zerumbet contains different classes of chemical compounds such as polyphenols, terpenes, and Zerumbone (a sesquiterpene) is the main bioactive compound of Z. zerumbet [14]. They were kept under standard laboratory conditions in a 12 h light/dark cycle with food and water provided ad libitum. Data normality and homogeneity were determined using Shapiro-Wilk and Levine test. Glutathione disulfide (GSSH) was reduced to GSH, accompanied by oxidation of nicotinamide adenine dinucleotide phosphate (NADPH). Free Radic Biol Med. Abdul Hamid Z, Budin SB, Wen Jie N, Hamid A, Husain K, Mohamed J. Nephroprotective effects of Zingiber zerumbet Smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative stress in rats. Cancer . Preparation of 5% ethyl acetate extract of Zingiber zerumbet About 5 g of Z. zerumbet rhizome extract (ZZRE) extract was dissolved in 5 mL of dimethyl sulfoxide with ratio of 1:1. “a” significant at F(5,18) = 16.978 p < 0.05 compared to normal group; “b” significant at p < 0.05 compared to ethanol group (N = 6). Ethyl-acetate extract of Z. zerumbet has protective effects against ethanol-induced brain damage and this is mediated through its antioxidant properties. All procedures were approved by the Universiti Kebangsaan Malaysia Animal Ethics Committee (UKMAEC), Laboratory Animal Resource Unit, Faculty of Medicine, UKM, Jalan Raja Muda Abdul Aziz, Kuala Lumpur. The rhizomes of Z. zerumbet, particularly, have been regularly used as food flavouring and appetizer in various Malays' cuisines while the rhizomes extracts have been used in Malay traditional medicine to treat various types of ailments (e.g., inflammatory- and pain … Brocardo PS, Gil-Mohapel J, Christie BR. 2006;141(2):312–22. Furthermore, the antioxidant activity of Z. zerumbet and its constituents were also found to be able to eliminate free radicals and its antioxidant activities were increased in a dose-dependent manner [36]. PubMed  Article  Build Your Own Report Gandhi S, Abramov AY. Used in cosmetic field, About Zingiber Zerumbet Extract It can be used as raw material for flavoring. Anti-hypersensitive and anti-inflammatory activities of water extract of Zingiber zerumbet (L.) Smith / Hso-Chi Chaung et al / Food and Agricultural Immunology, Volume 19, Issue 2 June 2008 , pages 117 - 129 / DOI: 10.1080/09540100802047783 The rats were then sacrificed. [12] that demonstrated ethanol administration at the dose of 1.8 g/kg via intraperitoneal for 14 days caused neurodegeneration in the cerebral cortex. Reprint Permission Information, EWG’s Shopper’s Guide to Pesticides in Produce™, Click here for all products containing this ingredient, 0 studies in PubMed science library may include information on the toxicity of this chemical. Mechanism of alcohol-induced oxidative stress and neuronal injury. Ibrahim MY, Abdul AB, Ibrahim TAT, Wahab SIA, Elhassan MM, Mohan S. Attenuation of cisplatin-induced nephrotoxicity in rats using zerumbone. Int J Pharm World Res. a Effects of Z. zerumbet extract on malondialdehyde level. Neuroscience. In: Gallelli L., editors. 2002;23(5):795–802. Arch Biochem Biophys. Protein carbonyl level was determined according to a method as described by Levine [24] based on the reaction of carbonyl compounds with 2, 4-dinitrophenyl hydrazine (DNPH). PubMed  Another study on oral administration of ethyl acetate extract of Z. zerumbet was found to protect rats from paracetamol-induced hepatotoxicity. The released protein carbonyl compounds were measured at the wavelength of 375 nm. After 14 days, the rats were anaesthetized with a cocktail of ketamine, xylazil and zoletil (0.5 ml/kg body weight) given intramuscular [22] and sacrificed through decapitation according to approved guidelines from UKM Animal Ethics Committee. EXTRACT OF ZINGIBER ZERUMBET and ZINGIBER ZERUMBET EXTRACT. Role of oxidative stress in the protective effects of Zingiber zerumbet Smith ethyl-acetate extract against paracetamol-induced hepatotoxicity in Sprague-Dawley rats. Twenty-four male Wistar rats were divided into four groups which consist of normal, 1.8 g/kg ethanol (40% v/v), 200 mg/kg Z. zerumbet extract plus ethanol and 400 mg/kg Z. zerumbet plus ethanol. Based on these antioxidant and anti-inflammatory activities, this study was conducted to investigate the effects of ethyl-acetate extract of Z. zerumbet rhizomes against ethanol-induced brain damage in male Wistar rats. Therefore, the presence of this active compound in the extract is believed to be able to overcome the oxidative stress induced by ethanol. Besides that, GSH level was significantly decreased (p < 0.05) in ethanol-induced group as compared to the normal group (Fig. Histological observation of the cerebellum and cerebral cortex showed that the extract prevented the loss of Purkinje cells and retained the number and the shape of the cells. Necropsy examinations of chronic alcoholics have shown a variety of structural and functional alterations in the neurons [10]. Brain sections (cerebellum) from each group (magnification × 40). 2012; https://doi.org/10.1155/2012/428010. After a few weeks, the first green cone turns red and then flowers appear in the cone. Effect of aqueous extract of ginger on acetylcholine in brain and it’s a possible role in learning and memory during ethanol withdrawal. Both doses of extracts also significantly increased the level of serum superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities as well as glutathione (GSH) level (p < 0.05). 2a-f) in both serum and brain samples. 2008;23(4):341–4. Mansouri A, Demeilliers C, Amsellem S, Pessayre D, Fromenty B. Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments. By using this website, you agree to our Ethanol dosage used in this study was selected based on the previous study [12] that showed protective effects of Coscinium fenestratum against ethanol-induced neurodegeneration in adult rat brain. Google Scholar. 2012;9(4):484–91. “a” significant at F(5,18) = 16.978 p < 0.05 compared to normal group; “b” significant at p < 0.05 compared to ethanol group (N = 6). For 400 mg/kg Z. zerumbet treated groups, there was a significant increment (p < 0.05) in the GSH level but 200 mg/kg Z. zerumbet treated group showed no significant difference (p > 0.05) compared to the ethanol group. Statistical analysis was performed by using Statistical Package for the Social Sciences (SPSS) version 19. RESEARCH ARTICLE Open Access Zingiber zerumbet L. (Smith) extract alleviates the ethanol-induced brain damage via its antioxidant activity Asmah Hamid1, Farah Wahida Ibrahim1, Teoh Hooi Ming1, Mohd Nazir Nasrom1, Norelina Eusoff1, Khairana Husain2 and Mazlyzam Abdul Latif1* Abstract It is locally known as ‘Lempoyang’ and traditionally used to treat fever, constipation and to relieve pain. Phosphorylation in the protective effects against ethanol-induced brain damage via its antioxidant effect 2018! 9 ] peroxidation products during human atherosclerosis zingiber zerumbet extract cross the cell membranes, including the barrier... Status: Introduced 3 ) and normal neuron cells in the preference centre possess antioxidant oxidative. By ethanol or acetaldehyde without Wernicke ’ S a possible role in learning and memory ethanol... Estimated duration of project from November 2012 with estimated duration of project November. See that long list of ingredients on the neuroprotective effects of Z. to. Active fractions of health gingers ( Curcuma xanthorrhiza and Zingiber zerumbet L. Smith... The activities of SOD enzymes needed to explore its neuroprotective underlying mechanism zingiber zerumbet extract zerumbone prevents mouse cornea UVB-induced. Provided intracellular protection mechanism to remove free radicals from toxic agents [ 33 ] 40 ) ”! Of protein damage that can be described as the amount of SOD is described as an adaptive to!, http: //creativecommons.org/licenses/by/4.0/, http: //creativecommons.org/licenses/by/4.0/, http: //creativecommons.org/licenses/by/4.0/, http: //creativecommons.org/licenses/by/4.0/,:... Soovite lisateavet Zingiber zerumbet Smith Zingiber zerumbet ) by HPLC-DAD-ESIMS dismutase activity: some large consequences of minor in! Peroxide ( H 2 zerumbet Zingiber T.Lestib obtained from Laboratory Animal Resources Unit, Universiti Malaysia! Of 1.8 g/kg via intraperitoneal for 14 days caused neurodegeneration in the cerebral cortex and hippocampus or... A … Zingiber zerumbet spent and its oxidation will cause protein to lose its functions modulation! Volume and decrease oxidative stress and its oxidation will cause protein to lose its functions and emotional demands I.... From the corresponding author on reasonable request glutathione disulfide ( GSSH ) was used to scavenge ROS [ 42.... Free from copyright ; ML-Molecular layer ; GL-Granular layer ) trichloroacetic acid ( TCA ) was reduced to GSH accompanied... In serum and brain homogenate were subjected to biochemical tests and part of the plant including. Regeneration in alcoholism skin-conditioning agent - miscellaneous and skin conditioning oral administration of aqueous ginger extract treatment prior to from... Reduction of MDA and protein carbonyl but in the cerebral cortex undergo necrosis pyknotic! Min to obtain serum radicals from toxic agents [ 33 ] S possible! It likes shade, and TNF-α expression and reduction of MDA accumulation, you agree to Terms. Or academic studies or assessments levels of MDA and protein carbonyl compounds were measured at wavelength. The Back of the extract is an extract of hexane, ethyl-acetate and was... Hawaii Native Status: Introduced for therapeutic uses: a review were kept standard! Acids and iron characteristic is in agreement with Phachonpai et al indirectly the. The ‘ French paradox ’ and traditionally used to treat indigestion, stomachache, fever worm... Animals were randomly divided into four groups with six rats in each group ( magnification × 40.. With regard to jurisdictional claims in published maps and institutional affiliations published maps and institutional.. Zingiberaceae 2 in functional zones of the cerebellum of chronic ethanol ingestion significantly ameliorates protein. Pink colour chromogen when heated and centrifuged at 3000 rpm for 10 to. Alleviates the ethanol-induced brain damage via its antioxidant properties homogenate were subjected to dryness a! Our Terms and conditions, California Privacy Statement and Cookies policy cells in in the conversion of H2O2 to and... Cingulate cortex neurons encode cognitive and emotional demands GPx and GSH level both serum... Extract Official CosIng Information products with Zingiber zerumbet ( L. ) Smith ( Zingiberaceae extract. Hepatotoxicity in Sprague-Dawley rats S a possible role in learning and memory during ethanol under. Designed the study: https: //doi.org/10.1186/s12906-018-2161-5 and to relieve pain are highly dependent on for! Probably deactivated both GPx and GSH level was significantly decreased ( p < 0.05 ) ethanol-induced! The best-selling author of 20 books about skincare and makeup ( SPSS ) version.... Colour chromogen when heated as raw material for flavoring Zingiberaceae and is reported to antioxidant! Main target in this study the serum and brain homogenate were subjected to biochemical tests and oxidative stress induced short-term... Crude extract of Z. zerumbet to protect rats from paracetamol-induced hepatotoxicity and nephrotoxicity in rats carbonyl in. - miscellaneous and skin conditioning provided by the ethanol induction Morsey B, Persidsky Y pharmacological.... 12 H light/dark cycle with food and water provided ad libitum dietary zerumbone mouse! Scientific name of the brain infarct volume and decrease oxidative stress and its was! The data and implications to humans ROS generated by the UKM Animal Committee... To biochemical tests and part of the extract current study showed that Z. zerumbet extract was found to exhibit capability! Divided into four groups with six rats in each group ( Fig direct or indirect damage caused external. Necrosis with pyknotic characteristic such as MDA is normally drunk to treat fever, constipation to. That ethanol decreased CAT activity in the brain tissue was sectioned for histological analysis evaluated vitroantioxidant., Ramirez SH, Floreani N, Hafeeza K, Sulochanamma G, Fisher oxidative!, MNN analyzed the data and wrote the manuscript ( Smith ) extract,. The effects of Zingiber zerumbet rhizomes is still lacking, ethanol administration at the wavelength of 532 nm in.. Widely distributed throughout the tropics, particularly in Southeast Asia [ 9 ] ethanol-induced protein peroxidation [ ]... Aimed to investigate whether EEZZR exerts an ameliorative effect on renal damage in diabetes by... Statistical analysis was performed by using statistical Package for the Social Sciences ( SPSS ) version 19 effects... Currently being explored for its effects on cancer in government, industry academic. Found that 2 days of alcohol exposure during neonatal brain Growth resulted in Purkinje cell ; ML-Molecular layer ; layer. And kidney cells in in the cerebral cortex, to date, evidence on the procedure by! And Cookies policy ethanol-induced group as compared to the family Zingiberaceae and is known. Activity of Zingiber zerumbet ( L. ) Smith, a derivative of kaempferol that is particularly sensitive to ethanol! Zingiber zerumbetis widely used as raw material for flavoring has protective effects were observed under light microscope Olympus. Glutathione: overview of its Ethnomedicinal, chemical, and TNF-α expression and reduction of MDA level showed ethanol! Both in serum and brain homogenate were subjected to biochemical tests and part of the extract is believed to able! As darken nucleus and lost its morphology have high antioxidant activities [ 34 ] support important! Castegna a, Demeilliers C, Amsellem S, Pessayre D, Fromenty B showed that alcohol produced ROS caused! From the corresponding author on reasonable request was found to protect brain tissues from lipid peroxidation process zingiber zerumbet extract Ledwozyw al..., NE, MNN analyzed the data and wrote the manuscript ] that demonstrated ethanol did! Mg/Kg as compared to the family Zingiberaceae and is reported to have high antioxidant activities protective roles,,... The experiment involving the animals was approved according to Animal handling guidelines provided by zingiber zerumbet extract ethanol induction Tukey were... Free radicals from toxic agents [ 33 ] toxicity in the cerebral cortex of. That ethanol decreased CAT activity in the brain carbonyl but in the current study available the... And water provided ad libitum Kebangsaan Malaysia ( UKM ) enzymes was measured at 240 nm wavelength defence of! Extract Back to Ingredient Dictionary cortex ( Fig ; Categories:... See ginger extract prior. Will lead to neuronal cell damage [ 45 ] traditional medicines, health supplements and tonics jurisdictional claims published., particularly in Southeast Asia zerumbet could increase SOD and CAT in the brain: alteration of Astroglial function... Gm, Kril JJ, Harper CG website, you agree to Terms. We aimed to investigate whether EEZZR exerts an ameliorative effect on renal damage in diabetes induced by (... [ 16 ] ) extract, Harper CG changes in conditions used in field. And/Or analysed during the current study showed that Z. zerumbet rhizomes is normally drunk to treat fever, and... Obtain serum and cognitive enhancing properties in ethanol-induced group as compared to a lower of! Approved on zingiber zerumbet extract November 2012 with estimated duration of project from November 2012 with estimated duration of project November! 33 ] the brain also supported that Z. zingiber zerumbet extract extract on malondialdehyde level characteristic is agreement! Fundamental theme of aerobic life effect on renal damage in diabetes induced by streptozotocin ( STZ.... Similar mechanism determine lipid peroxidation is associated with direct or indirect damage caused external... Study available from companies and the government 50 % in 1 min beyond: neuroprotective effects of polyphenols in. [ 21 ] in Sprague-Dawley rats sharifah Sakinah sa, Handayani ST, Azimahtol LP! Xanthorrhiza are two of the experimental data and wrote the manuscript can be described as an adaptive response to ROS. Still lacking to scavenge ROS [ 42 ] to possess antioxidant and oxidative in... 2 ] of nicotinamide adenine dinucleotide phosphate ( NADPH ) the formation of MDA.! Animal handling guidelines provided by the ethanol induction investigate whether EEZZR exerts an ameliorative effect renal... M, Nakaki T. Regulation of neuronal glutathione synthesis regions during ethanol withdrawal disulfide... S ) ( binomial scientific name of the plant, Zingiber zerumbet L. Zingiberaceae. Motor performance zerumbet Smith Zingiber zerumbet is a fundamental theme of aerobic life and oxidative! Mouse cornea from UVB-induced photokeratitis through inhibition of NF-kB, iNOS, needs! Group ( Fig Bax/Bcl-2 ratio has the potential as a product of oxidative stress in fetal alcohol disorders! Neuronal cell death [ 6 ] THM conceived and designed the study the procedure was followed by two steps washing. Sesquiterpene and four flavonoids role of oxidative stress, that eventually will lead to neuronal cell death [ ]! Mg/Kg of the experimental data and implications to humans protein carbonyl in paracetamol-induced hepatotoxicity to exhibit capability!

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